Assessing Pulmonary Epithelial Damage in Hantavirus Cardiopulmonary Syndrome: Challenging the Predominant Role of Vascular Endothelium through sRAGE as a Potential Biomarker

Hantavirus cardiopulmonary syndrome (HCPS) is a severe respiratory illness primarily associated with microvascular endothelial changes, particularly in the lungs. However, role of pulmonary epithelium HCPS pathogenesis remains unclear. This study explores potential soluble Receptors for Advanced Glycation End-products (sRAGE) as biomarker assessing epithelial damage HCPS, challenging prevailing view that dysfunction sole driver this syndrome. We conducted cross-sectional on critically ill patients, categorizing them into mild and negative control groups. Plasma sRAGE levels were measured, revealing significant differences between group controls. Our findings suggest holds promise an indicator injury may aid tracking disease progression guiding therapeutic strategies. brings clarity importance investigating epithelium’s pathogenesis, offering avenues enhanced diagnostic precision support critical public health concern.